Striae distensae are commonly formed on the abdomen, thighs and some other body sites and the aetipathogenesis is multifactorial, including following pregnancy or as a result of significant changes in body mass, genetic pre-disposition, growth spurts in puberty or as an association with Marfans or Cushings syndromes. They are twice as common in females, compared to males, and display as linear scars, initially with a significant erythematous appearance and often with itch (striae rubra or striae gravidarum), which fades to silvery grey over a period of several years (striae alba). Histologically, the change from striae rubra to alba involves distension and tearing of elastic fibres, initial inflammatory cell involvement and eventual thinning of the epidermis. Several treatments are available that claim to improve the appearance of striae including laser ablation, intense pulsed light and other minor surgical approaches. In addition, there are several cosmetic products available that similarly claim to improve the visible appearance of striae. In this study, we will present results from a study to evaluate the biophysical changes in the skin of females with striae gravidarum that were less than 3 years since formation and whether regular use of a topical cosmetic product over 8 weeks could lead to changes in the biophysical measurements. Thirty female volunteers were recruited from the test panel at Cutest Systems Ltd, Cardiff, U.K. who met the inclusion and exclusion criteria and who consented to enter the study. Baseline measurements of skin moisturization using a Corneometer™, skin elasticity using a Cutometer™ and skin colour adjacent to and over the striae, using a Chromameter™ were made. In addition, standardized digital images were taken of the striae with a Canon DSLR and controlled lighting and volunteers completed self-evaluation questionnaires. In addition to the biophysical measurements, dermatoscopic images and invivo confocal images were taken of selected striae using a Canfield VisioMed D200™ and Vivascope 150™ instrument respec. The volunteers were given a cosmetic body product (cream) to apply to the abdomen twice daily for 8 weeks. The volunteers were asked to return to the clinic after 4 weeks and again after 8 weeks of use for repeat measurements. The dermatoscopic images and invivo confocal images were taken only after 8 weeks. Data were compared statistically using ANOVA for multiple comparisons (Tukey-HSD method). Changes in moisturization of the skin were statistically significant at both 4 weeks and 8 weeks (p<0.001 for both), with Corneometer measurements changing from 26.55+6.12 a.u. at baseline to 36.09+10.50 a.u. after 8 weeks. Skin colour measurements using the Chromameter™ a* values on the target striae changed from 5.35+1.63 units at baseline to 5.24+2.02 a.u. after 8 weeks, which was statistically significant (p=0.023). These preliminary data demonstrate an improvement in biophysical skin parameters following regular use of the cosmetic product. We will present the histological comparisons and clinical evaluation by the dermatologist and the complete dataset from the study in the full paper, in order to determine whether use of a cosmetic product for 8 weeks can result in clinically relevant changes in the appearance of striae and whether this is associated with histological changes as imaged using in vivo confocal microscopy.