Easystiff, the new device, easy-to use, to higlight the true stiffness and firmness of human skin in-vivo : study on skin well-aging.
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Presented by: Gael Runel
Human skin is particularly sensitive to ageing and undergoes profound structural and functional changes. These visible changes can affect our relations with others. Thus, developing effective products but also analytical equipments to guarantee their effectiveness is crucial.
During ageing, we observe a remodeling of the dermis with a decrease in the characteristics such as the quantity and structure of collagens, elastin, and other molecules, of the papillary compartment in favor of the reticular compartment accompanied by a flattening of the papillae. Organizational changes of the epidermis and a modification of the number of layers forming the SC are also shown. These structural changes irrevocably lead to biomechanical modifications of the tissue, resulting in sagging skin, loss of elasticity and wrinkling.
The data obtained with 3D in vitro skin models and ex-vivo skin models are not sufficient to understand the mechanisms involved in a whole organism. Thus, the biomechanical in-vivo study (i.e., on human volunteers) of the different compartments of the skin is an essential challenge to understand these mechanisms and eventually find the appropriate cosmetic formulas.
During a clinical study focused on ageing and the lower eyelid area, an area known to be very fragile, our own device was used to directly measure the stiffness of the different skin compartments. Based on a non-invasive surface deformation, the innovative measuring device EASYSTIFF® (BIOMECA, Lyon, France) is able to extract the true stiffness data from the different skin compartments: Stratum Corneum, epidermis, dermis and hypodermis.
The measurements of EASYSTIFF® are based on indentation. The central indentation aperture was 5mm in diameter with a prob size of 1mm. One force/distance cycle was used, consisting in a displacement of the prob into the skin for 2s at 2.7 mm deep (max), followed by the release of the device. The data processing consisted in applying a mathematical model (Hertz model) based on the force/distance curves recorded. Each curve was processed, and the elastic modulus was extracted: global and tomography.
Our study involved 18 female volunteers aged between 21 and 34 years old. The aim of this study was to study the ageing of the eyelid skin. We carried out a comparative study of the different skin compartments according to age against the overall analysis of the skin. This study revealed a decrease in the rigidity of the SC, epidermis, and dermis. These results show an inter-compartment variability that is indistinguishable from the global skin analysis. Thus, EASYSTIFF® enabled us to study the different skin compartments in a targeted manner. To go further, we were interested in studying two types of lower eyelids : vascularized eyelid and pigmented eyelid. This analysis by compartment revealed an increase in the rigidity of the 3 skin compartments, SC, epidermis and dermis, for the pigmented eyelids
During ageing, we observe a remodeling of the dermis with a decrease in the characteristics such as the quantity and structure of collagens, elastin, and other molecules, of the papillary compartment in favor of the reticular compartment accompanied by a flattening of the papillae. Organizational changes of the epidermis and a modification of the number of layers forming the SC are also shown. These structural changes irrevocably lead to biomechanical modifications of the tissue, resulting in sagging skin, loss of elasticity and wrinkling.
The data obtained with 3D in vitro skin models and ex-vivo skin models are not sufficient to understand the mechanisms involved in a whole organism. Thus, the biomechanical in-vivo study (i.e., on human volunteers) of the different compartments of the skin is an essential challenge to understand these mechanisms and eventually find the appropriate cosmetic formulas.
During a clinical study focused on ageing and the lower eyelid area, an area known to be very fragile, our own device was used to directly measure the stiffness of the different skin compartments. Based on a non-invasive surface deformation, the innovative measuring device EASYSTIFF® (BIOMECA, Lyon, France) is able to extract the true stiffness data from the different skin compartments: Stratum Corneum, epidermis, dermis and hypodermis.
The measurements of EASYSTIFF® are based on indentation. The central indentation aperture was 5mm in diameter with a prob size of 1mm. One force/distance cycle was used, consisting in a displacement of the prob into the skin for 2s at 2.7 mm deep (max), followed by the release of the device. The data processing consisted in applying a mathematical model (Hertz model) based on the force/distance curves recorded. Each curve was processed, and the elastic modulus was extracted: global and tomography.
Our study involved 18 female volunteers aged between 21 and 34 years old. The aim of this study was to study the ageing of the eyelid skin. We carried out a comparative study of the different skin compartments according to age against the overall analysis of the skin. This study revealed a decrease in the rigidity of the SC, epidermis, and dermis. These results show an inter-compartment variability that is indistinguishable from the global skin analysis. Thus, EASYSTIFF® enabled us to study the different skin compartments in a targeted manner. To go further, we were interested in studying two types of lower eyelids : vascularized eyelid and pigmented eyelid. This analysis by compartment revealed an increase in the rigidity of the 3 skin compartments, SC, epidermis and dermis, for the pigmented eyelids