13:40 - 15:10
Workshop 9, “Anti-cytokine therapy for inflammatory human diseases”
Room: ANA Crowne Plaza “Ohtori” Room B
Workshop Session
Chair/s:
John A. Hamilton, Yoshiya Tanaka
13:40 - 13:55
Tu-WS9-1
Overview of anti-cytokine therapy and differential use of biologics based on lymphocyte phenotype in inflammatory autoimmune diseases
Yoshiya Tanaka
The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
13:55 - 14:10
Tu-WS9-2
TNFR2+ REGULATORY T CELLS (Tregs) SUBPOPULATIONS ARE HIGHLY SUPPRESSIVE AND ARE INCREASED ON ANTI-TNF TREATMENT IN RHEAUMTOID ARTHRTIS (RA) PATIENTS.
François Santinon1, Maxime Batignes1, Benoit Salomon2, Jorg Tost4, Florence Busato4, Patrice Decker1, Marie-Christophe Boissier1, 3, Luca Semerano1, 3, Natacha Bessis1
1INSERM UMR 1125, Sorbonne Paris Cité, University Paris 13, 75011 Paris, France, 2Sorbonne Universities, UPMC University Paris 06, INSERM, CNRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France, 3Assistance Publique-Hôpitaux de Paris (AP-HP), Avicenne Hospital, Rheumatology Dept, Bobigny, France, 4Laboratory for Epigenetics and Environment, Centre National de Génotypage, CEA-Institut de Génomique,, Evry, France
14:10 - 14:25
Tu-WS9-3
TRAIL suppresses joint inflammation and osteoclastogenesis through inhibiting activated T cell responses in inflammatory arthritis
I-Tsu Chyuan1, 2, Hwei-Fang Tsai3, 4, Ping-Ning Hsu5, 6
1Department of Internal Medicine, Gathay General Hospital, Taipei, Taiwan, 2Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, 3Department of Internal Medicine, Taipei Medical University Shuang Ho Hospita, Taipei, Taiwan, 4Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, 5Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, 6Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan
14:25 - 14:40
Tu-WS9-4
Distinct single cell gene expression signatures of monocyte subsets differentiate between TNF-alpha inhibitor treatment response groups in Rheumatoid Arthritis
Theresa L. Wampler Muskardin1, Wei Fan5, Zhongbo Jin4, Mark A. Jensen2, Jessica M. Dorschner3, Yogita Ghodke-Puranik3, Danielle Vsetecka3, Timothy B. Niewold2
1NYU Langone Medical Center, Department of Medicine, Division of Rheumatology, New York, United States, 2NYU Langone Medical Center, Department of Medicine, Colton Center for Autoimmunity, New York, United States, 3Mayo Clinic, Department of Medicine, Division of Rheumatology, Rochester, United States, 4University of Florida School of Medicine, Department of Pathology, Immunology, and Laboratory Medicine, Gainesville, United States, 5Shanghai Jiao Tong University, School of Medicine, Ren Ji Hospital, Department of Rheumatology, Shanghai, China
14:40 - 14:55
Tu-WS9-5
Anti-CX3CL1 monoclonal antibody therapy suppresses the development of bleomycin-induced and growth factors-induced skin fibrosis in mice
Vu Huy Luong1, Takenao Chino1, Noritaka Oyama1, Takashi Obara2, Yoshikazu Kuboi3, Naoto Ishii3, Akihito Machinaga3, Hideaki Ogasawara3, Wataru Ikeda3, Toshio Imai3, Minoru Hasegawa1
1Department of Dermatology, Fukui University, Fukui, Japan, 2Eisai Co..Ltd., Tokyo, Japan, 3KAN Research Institute.Inc., Hyogo, Japan
14:55 - 15:10
Tu-WS9-6
A new GM-CSF-dependent pathway in inflammation
John A. Hamilton
University of Melbourne, Department of Medicine at Royal Melbourne Hospital, Parkville, Australia