13:40 - 15:10
Workshop 5, “Genetic disorders in cytokines and inflammation”
Room: ANA Crowne Plaza “Ohtori” Room C
Workshop Session
Chair/s:
Koji Yasutomo, Warren Leonard
13:40 - 14:00
Mo-WS5-1
Genetics of familial inflammatory disorders
Koji Yasutomo
Tokushima University, Tokushima, Japan
14:00 - 14:10
Mo-WS5-2
Mutation of arginine 285 in IRF3 to glutamine selectively impairs activation of IRF3 by STING and TRIF dependent pathways.
Line Lykke Andersen1, Louise Kragh Dalskov1, Hans Henrik Gad1, Trine Hyrup Mogensen2, Rune Hartmann1
1Department of Molecular Biology and Genetics, Aarhus University, Aarhus. Denmark., Aarhus, Denmark, 2Department of Infectious Diseases, Aarhus University Hospital,, Aarhus, Denmark
14:10 - 14:20
Mo-WS5-3
ADAR1 Deficiency Linked to Aicardi-Goutiéres Syndrome Causes Cell Death from RNase L Activation
Robert H Silverman1, Shuvojit Banerjee1, Yize Li2, Manisha Talukdar3, Stephen A Goldstein2, Beihua Dong1, Frank Sicheri3, Susan R Weiss2
1Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States, 2Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States, 3Program in Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
14:20 - 14:40
Mo-WS5-4
γc Family Cytokines, Immunodeficiency, and the Fine-tuning of Cytokine Signaling
Warren Leonard, Peng Li, Suman Mitra, Edwin Wan, Rosanne Spolski, Jian-Xin Lin
Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, Bethesda, United States
14:40 - 14:50
Mo-WS5-5
XIAP deficiency results in excess NLRP3 inflammasome activation and cell death as a consequence of TLR-MyD88 induced cIAP1-TRAF2 degradation
Kate Lawlor1, 2, Rebecca Feltham1, 2, Monica Yabal3, Stephanie Conos1, 2, Kaiwen Chen4, Tan Nguyen1, 2, Cathrine Hall1, Simon Chatfield1, 2, Damian D'Silva1, Kenneth Pang5, Kate Schroder4, John Silke1, 2, David Vaux1, 2, Philipp Jost3, James Vince1, 2
1Walter and Eliza Hall Institute of Medical Research, Parkville, Australia, 2Department of Medical Biology, The University of Melbourne, Parkville, Australia, 3III. Medical Department for Hematology and Oncology, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany, 4Institute for Molecular Bioscience and Centre for Inflammation and Disease Research, The University of Queensland, St Lucia, Australia, 5Department of Paediatrics, University of Melbourne, Parkville, Australia
14:50 - 15:00
Mo-WS5-6
Gain of function of MDA5 in CD11c-expressing cells is sufficient to induce lupus-like nephritis
Shota Shimizu1, 2, Yuki Shimada1, 2, Hiroki Kato1, 2, Takashi Fujita1, 2
1Laboratory of Molecular Genetics, Department of Genetics and Molecular Biology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan, 2Laboratory of Molecular and Cellular Immunology, Department of Molecular and Cellular Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
15:00 - 15:10
Mo-WS5-7
Virus-induced IFN-λ4 potently blocks IFN-α signaling by ISG15/USP18 in HCV infection
Seon-Hui Hong
Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of (South)