19:10 - 21:00
Poster Session 3 “Cytokines in skin inflammatory diseases”
Room: Ishikawa Ongakudō Interchange Hall
Poster Session
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Clec10a suppresses house dust mite-induced dermatitis
Kazumasa Kanemaru1, Emiko Noguchi2, Kaori Denda-Nagai4, Tatsuro Irimura4, Satoko Tahara-Hanaoka1, 3, Akira Shibuya1, 3
1Department of Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan, 2Department of Medical Genetics, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan, 3Life Science Center of Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Ibaraki, Japan, 4Division of Glycobiologics, Intractable Disease Research Center, Juntendo University School of Medicine, Hongo, Bunkyo-ku, Tokyo, Japan

Although a C-type lectin receptor Clec10a is expressed on macrophages and dendritic cells, its function in immune responses by these myeloid cells remains incompletely understood. Here we examined whether Clec10a is involved in house dust mite (HDM)-induced allergic dermatitis.
Wild-type (WT) and Clec10a-/- mice on the C57BL/6J mice background were topically applied with HDM on the skin. Clec10a-/- mice showed more severe dermatitis, larger number of neutrophil infiltration in the skin, and higher expression of Il6, Cxcl1, and Cxcl2 in dermal MHCII+CD3-B220-Ly6G-NK1.1-EpCAM-CD64+ macrophages (MPs) than did WT mice after the treatment.
Clec10a, as well as Toll-like receptor 4 (TLR4), directly bound to HDM through its galactose-binding portion and suppressed TLR4-mediated secretion of inflammatory cytokines, including IL-6, CXCL1, CCL3, and TNF-α from bone marrow-derived cultured MPs. These results suggest that Clec10a is an inhibitory receptor for HDM-induced allergic dermatitis.

Reference:
Mo-P3-9
Session:
Poster Session 3 “Cytokines in skin inflammatory diseases”
Presenter/s:
Kazumasa Kanemaru
Presentation type:
Poster Presentation
Room:
Ishikawa Ongakudō Interchange Hall
Date:
Monday, 30 October 2017
Time:
19:10 - 21:00
Session times:
19:10 - 21:00
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