Ayurveda of India, commonly practiced in subcontinent including Pakistan, has a published history preceding to 1500 BCE and its reliance is established most recently in a genomic SNP (single nucleotide polymorphism) based analysis, that confirms the genetic basis of Ayurveda. Moreover, it was also established that Prakriti approach (Genetic makeup of every human) of Ayurveda practice simply resounds with concept of modern personalized medicine. We explored a constituents of traditional herbal formulation that also serves as functional food. The Ferula narthex Boiss. (Apiaceae), Ziziphus numularia (Burm.f.) Wight & Arn. (Rhamnaceae) and six different Citrus species (Citrus sinensis (L.) Osbeck , Hybrid of Citrus nobilis and Citrus delicense, Citrus paradisi Macfad, Citrus aurantifolia Christm. and Citrus limon (L.) Burm. f. from Pakistan were explored for detailed phytochemical analysis and biological activities. The ligupersin A isolated from Ferula narthex presented highest antiglycation activity (IC50 0.414 mM) in BSA-glucose model whereas, being more active than in BSA-MGO assay, highest activity was shown by 8′-O-acetyl-asacoumarin A (IC50 1.03 mM). In case of Z. nummularia (in DPPH assay), the methanolic fraction presented highest activity (IC50 193.1 µ g/ml), followed by ethyl acetate (IC50 220 µ g/ml) and chloroform (IC50 263 µ g/ml) fractions. The FRAP value for ethyl acetate fraction recorded as highest ( 370.2 µM). During the antibiofilm assay, n -hexane fraction presented highest inhibition (88%) followed by ethyl acetate (69%) chloroform (65%) fractions. The extracts also presented interesting results towards diabetes, and inflammation. Likewise the citrus peel extracts presented significant antidiabetic, antimicrobial, antiinflmmatory properties that could be mainly contributed by flavonoids . It was therefore concluded that indigenous herbal formulation effectively helps in management of diabetes and allied comorbidities.