The changes of chemical and biological activities of materials at a nanoscale may result in unique interactions with biological systems. This fundament directly relates to many newly emerging frontier sciences in multidisciplinary fields, e.g., nanomedicine, nanobiotechnology, nanotoxicology, nanobiomedical engineering, cancer nanotechnology, etc. So far, the key discoveries for nanomedicines (NMs) and NMs-interacting with biosystems include, (i) NMs maybe a best candidate for development of the next generation of medicine (called as nanomedicine), (ii) NMs easily penetrate biological barriers, (iii) NMs easily adsorb blood proteins (protein corona), (iv) NMs easily cross cell membrane to enter cells and induce intracellular ROS generation, (v) nanosizes and nanosurface chemistry largely determine functions and fates of NMs in vivo or in vitro, etc. In the talk, we will discuss the new achievements of smart nanomaterials targeting and regulating tumor microenvironment to improve the therapeutic outcomes for cancer treatment.
Reference:
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[2] Han X.X; Nie G. J., Zhao Y.L., et al., Nature Communication, 2018, in press.
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