TCM is developing to modernization and internalization based on inheriting the essential tradition. In modern studies of TCM decoction slices, ultrafine granular powder (UGP), which are shivered into ultrafine powder (D90 < 45 µm before granulation) from single species of TCM decoction slices and then reshaped as granules, is a novel type. UGP overcomes the disadvantages such as poor homogeneity, unsure safety and quality in traditional decoction slices (TDS). After cells-cracked, the utility of ingredients can be maximized. With convenient and diverse application ways, UGP can be brewed, decocted or stirred into a suspension (just like the coffee form).
Comparative studies on traditional decoction slices and UGP of Chinese Salvia is an example research including chemical analysis, contents of major components, in vitro dissolution and in vivo pharmacokinetics, pharmacology, safety and stability. The chemical profiles of TDS and UGP were compared via similarity analysis and discriminated via multivariate analysis. The mean similarity correlation coefficient (> 0.987) revealed that UGP and TDS of Chinese Salvia were consistent between each other and stable between different batches. Compounds were further characterized by ESI-MS/MS. Eventually, 62 compounds selected as characteristic markers for evaluation were characterized or tentatively characterized. Meanwhile, compared with TDS, UGP showed significant cardio-protection against myocardial remodeling with therapeutic treatment. Results show that UGP also holds the advantages of uniform, convenience and efficiency. Undoubtedly, UGP can bring about great changes for clinical treatment.
Quality standard system of UPG has been established and developed gradually. In the near future, UPG with Chinese cultural characteristics will definitely step into the international medical and healthcare market, being an important natural and innovative category for human health, intervention in sub-health and clinical use.