16:00 - 18:00
Room: Poster Area - Poster Shed
Poster Presentation
Nitric oxide inhibitory constituents from Lysimachia foenum-graecum
Jun Gu Kim, Hari Jang, Jae Sang Han, Thi Phuong Linh Le, Hye Ryeong Hong, Jun Hwi Ko, Mi Kyeong Lee, Bang Yeon Hwang
Department of pharmacy, Chungbuk national universtiy,, Cheongju-si

The plant of Lysimachia foenum-graecum (primulaceae) has been used as traditional medicine to treat cold, headache, inflammation, and diseases of digestive system.[1] Previous phytochemical investigations of this plant have led to the isolation of bioactive compounds such as flavonoids and triterpene saponins.[2] The aim of the present research is to isolate and identify anti-inflammatory agents from medicinal plants. Bioassay-guided fractionation of the n-BuOH soluble fraction of the aerial parts of L. foenum-graceum led to the isolation of seven new oleanane-type triterpene saponins (1-7), which contains angeloyl and acetyl groups in the aglycone. Their structure were elucidated on the basis of spectroscopic methods such as 1D-, 2D-NMR, and HR-ESI-MS. Isolated compounds were evaluated for their inhibitory effects on the NO production against LPS-induced RAW 264.7 macrophages, and showed significant inhibitory effects with IC50 values ranging from 1.6 to 47.9 μM.

[1] Huang XA, Shen XL, Hu YJ, Liu YM, Liu KL, Zhang FX, Zhou XX. Molecules 2011; 16: 8076-8082.

[2] Kohda H, Takeda O, Tanaka S. Chemical & pharmaceutical bulletin 1989; 37:3304-3305.


Reference:
Poster Session-PO-82:
Session:
Poster Presentation-1
Presenter/s:
Jun Gu Kim
Presentation type:
Poster presentation
Room:
Poster Area - Poster Shed
Date:
Monday, 27th August, 2018
Time:
16:00 - 18:00
Session times:
16:00 - 18:00