16:00 - 18:00
Room: Poster Area - Poster Shed
Poster Presentation
Inhibitory effects of Anemarrhena asphodeloides and major constituent in acute lung injury model
Ki Sun Kwon 1, Hyun Lim 1, Kyung Su So 1, Yong Soo Kwon 1, Kun Ho Son 2, Soon Youl Kwon 3, Hyun Pyo Kim 1
1 College of Pharmacy, Kangwon National University, Chuncheon
2 Department of Food and Nutrition, Andong National University, Andong
3 Gyeongbuk Institute for Bio Industry, Andong

The rhizomes of Anemarrhena asphodeloides have a long history of use against lung inflammatory disorders in traditional herbal medicine. However, the therapeutic potential of this plant material in animal models of lung inflammation has yet to be evaluated. In the present study, we prepared the alcoholic extract and derived the saponin-enriched fraction from the rhizomes of A. asphodeloides and isolated timosaponin A-III, a major constituent. Lung inflammation was induced by intranasal administration of lipopolysaccharide (LPS) to mice, representing an animal model of acute lung injury (ALI). The alcoholic extract (50 – 200 mg/kg) inhibited the development of ALI. Especially, the oral administration of the saponin-enriched fraction (10 – 50 mg/kg) potently inhibited the lung inflammatory index. It reduced the total number of inflammatory cells in the bronchoalveolar lavage fluid (BALF). Histological changes in alveolar wall thickness and the number of infiltrated cells of the lung tissue also indicated that the saponin-enriched fraction strongly inhibited lung inflammation. Most importantly, the oral administration of timosaponin A-III at 25 – 50 mg/kg significantly inhibited the inflammatory markers observed in LPS-induced ALI mice. All these findings, for the first time, provide evidence supporting the effectiveness of A. asphodeloides and its major constituent, timosaponin A-III, in alleviating lung inflammation.


Reference:
Poster Session-PO-61:
Session:
Poster Presentation-1
Presenter/s:
Ki Sun Kwon
Presentation type:
Poster presentation
Room:
Poster Area - Poster Shed
Date:
Monday, 27th August, 2018
Time:
16:00 - 18:00
Session times:
16:00 - 18:00