Peanut or groundnut is mostly cultivated in Indonesia and it's also the second most important kind of nut after soybean in Indonesia. Peanut shell (Arachis hypogaea) is a dreg which contains fibre, saponins, phenols and polyphenols with one of them is procyanidin, which has been known to reduce cholesterol levels in blood plasma.1,2 The aim of this research was to investigate the antidyslipidemic activity of the ethanolic extract of peanut shell (PSEE) in the dyslipidemic rat model. The dyslipidemic condition was induced by feeding high-fat diet for 28 days. The antidyslipidemic effect was evaluated at three different doses (150, 300, 450 mg/kg BW) administered for 7 days. The PSEE showed a significant decreased in the serum triglycerides (TG), total cholesterol (TC), and low-density lipoprotein (LDL) as well as simvastatin. Moreover, the serum level of high-density lipoprotein (HDL) significantly increased accompanied by an increased HDL-C/TC ratio in a dose-dependent manner. Based on this investigation, it was concluded that PSEE possesses marked antidyslipidemic activity.
Acknowledgements: Ministry of Research, Technology and Higher Education Grant
Keywords: Arachis hypogaea, antidyslipidemic activity, triglyceride, total cholesterol, low-density lipoprotein, high-density lipoprotein
References:
- Adam J.M., S. Soegondo, G. Soemiardji, dan H. Adriansyah. 2004. Petunjuk Praktis Penatalaksanaan Dislipidemia. Jakarta: PB. PERKENI Hal. 1-14,20-26.
- Lou, H.X., Yamazaki, Y., Sasaki, T., Uchida, M., Tanaka, H., Oka, S., 1999. A-type procyanidins from peanut skin. Phytochemistry 51, 297–308.
- Natella, F., Belelli, F., Gentili, V., et al., 2002. Grape seed proanthocyanidins prevent plasma postprandial oxidative stress in humans. Journal of Agricultural and Food Chemistry 50, 7720-7725