16:00 - 18:00
Room: Poster Area - Poster Shed
Poster Presentation
Biological activities of the main compounds of the Chinese formulation Fang Feng Tong Sheng San
Stephanie Tscharre 1, Kathrin Briendl 1, Haiyu Zhao 2, Bian Baolin 2, Adelheid Brantner 1
1 University of Graz, Institute of Pharmaceutical Sciences, Graz
2 Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing

The Chinese formulation Fang Feng Tong Sheng San (FFTSS) is a mixture consisting of 17 different components [1]. Previous investigations proved the activities of the formulation and of preparations [2].

12 main compounds of FFTSS’s component herbs have been tested by in vitro bioassays for different activities.

Oxidative stress plays a significant role in aging processes and in the formation of cancer. The most potent antioxidants were gallic acid (IC50 4.50±0.05 μ g/ml), luteolin (IC50 4.67±0.50 μ g/ml) and baicalein (IC50 10.02±0.25 μ g/ml) compared to the reference rutin (IC50 12.66±0.84 μ g/ml). The most potent inhibitors of the lipidperoxidase were baicalein (IC50 0.37±0.03 μ g/ml), baicalin (IC50 2.50±0.05 μ g/ml) and luteolin (IC50 4.07±0.79 μ g/ml) (reference quercetin IC50 1.17±0.05 μ g/ml). Acetylcholinesterase and butyrylcholinesterase are important in the treatment of the Alzheimer’s disease. The most effective substances for inhibiting acetylcholinesterase were gallic acid (IC50 2.46±4.50 μ g/ml) and wogonin (IC50 15.32±3.10 μ g/ml) (reference eserin (IC50 0.35±0.06 μ g/ml). The most potent inhibitor for butyrylcholinesterase was luteolin (IC50 24.82±0.96 μ g/ml). Baicalin showed a similar inhibitory activity (IC50 288.38±18.46 μ g/ml) as the α -glucosidase inhibitor acarbose (IC50 346.68±4.36 μ g/ml) which is used for the treatment of diabetes mellitus type II. Baicalein (IC50 44.27±2.31 μ g/ml) und baicalin (IC50 54.90±1.46 μ g/ml) turned out to be also potent inhibitors of tyrosinase (reference ascorbic acid IC50 36.73±0.67 μ g/ml) which may play a role in the pathogenesis of the Parkinsons’s disease.

Acknowledgements: Financial support from the BMWF (GZ 402.000/00013-WFN/6/2016) and the CACMS is gratefully acknowledged.

References

[1 ] Pharmacopoeia of the People's Republic of China, Vol. 1, Beijing: Chemical Industry Press; 2015 : 409.

[2] Brantner A, Al-Ajlani M, Zhou Y, Zhao H, Bian B. IJPSR 2017; 8 (8): 3278-3286.


Reference:
Poster Session-PO-95:
Session:
Poster Presentation-1
Presenter/s:
Stephanie Tscharre
Presentation type:
Poster presentation
Room:
Poster Area - Poster Shed
Date:
Monday, 27th August, 2018
Time:
16:00 - 18:00
Session times:
16:00 - 18:00