16:00 - 18:00
Room: Poster Area - Poster Shed
Poster Presentation
Cytotoxic and cancer chemopreventive properties of prenylated stilbenoids from Macaranga siamensis
Vilailak Prachyawarakorn 1, Chulabhorn Mahidol 1, 2, Phanruethai Pailee 1, Somsak Ruchirawat 1, 2, 3
1 Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok
2 Chulabhorn Graduate Institute and the Chemical Biology Program, Kamphaeng Phet 6 Road, Laksi, Bangkok
3 Center of Excellence on Environmental Health and Toxicology (EHT), CHE, Ministry of Education, Bangkok

The genus Macaranga, which is one of the largest genera of the Euphorbiaceae family, contains approximately 280 species and is distributed between West Africa and the islands of the South Pacific [1]. In Thailand, 22 species have been recorded [1]. Some species has been used as a traditional Thai medicine for antipyretic, antitussive and anti-inflammatory treatment [2]. Mammea siamensis S.J. Davies is a large-leaved plant of the tropical dry seasonal forest and is common throughout central and northern Thailand. No previous chemical investigation of this plant has been reported. In this work, twenty-five new compounds, including prenylated stilbenene, flavonol, flavanone, resorcinol, and 1,4-phenanthraquinone derivatives, together with five known compounds, were isolated from the dichloromethane extract of the leaves and twigs of M. siamensis. Their structures were established using spectroscopic techniques. Their cytotoxic and antioxidant properties were evaluated together with their effectiveness as aromatase inhibitors.

References

  1. Davies SJ, Bunyavejchewin S. Lafrankie JV. Thai For. Bull. (Bot.) 2001; 29: 43-50.
  2. Phupattanapong L, Wongprasert T. Thai Medicinal plants. Part 5. Bangkok: Chutima publishing; 1987: 690.


Reference:
Poster Session-PO-37:
Session:
Poster Presentation-1
Presenter/s:
Vilailak Prachyawarakorn
Presentation type:
Poster presentation
Room:
Poster Area - Poster Shed
Date:
Monday, 27th August, 2018
Time:
16:00 - 18:00
Session times:
16:00 - 18:00