The genus Macaranga, which is one of the largest genera of the Euphorbiaceae family, contains approximately 280 species and is distributed between West Africa and the islands of the South Pacific [1]. In Thailand, 22 species have been recorded [1]. Some species has been used as a traditional Thai medicine for antipyretic, antitussive and anti-inflammatory treatment [2]. Mammea siamensis S.J. Davies is a large-leaved plant of the tropical dry seasonal forest and is common throughout central and northern Thailand. No previous chemical investigation of this plant has been reported. In this work, twenty-five new compounds, including prenylated stilbenene, flavonol, flavanone, resorcinol, and 1,4-phenanthraquinone derivatives, together with five known compounds, were isolated from the dichloromethane extract of the leaves and twigs of M. siamensis. Their structures were established using spectroscopic techniques. Their cytotoxic and antioxidant properties were evaluated together with their effectiveness as aromatase inhibitors.
References
- Davies SJ, Bunyavejchewin S. Lafrankie JV. Thai For. Bull. (Bot.) 2001; 29: 43-50.
- Phupattanapong L, Wongprasert T. Thai Medicinal plants. Part 5. Bangkok: Chutima publishing; 1987: 690.