Schisandra sphenanthera (Schisandraceae) has been used for the traditional medicines in Asia as a sedetive and anti-tussive agent and reported to have antihepatitis, antivial and anti-HIV activities. S.sphenanthera is widely distributed in the East-Asia and Southeast Asia. Using various chromatographic resins and isolation techniques, a new lignan, 4-(3,4-dimethoxyphenyl)-4-hydroxy-3-methlbutan-2-yl-dimethoxybenoate (1) along with six known lignan derivatives (2-7), one new nortriterpenoid, sphenadilactone G (8) with four knonw nortriterpenoids (9-12), three known phenolic compounds (13-15) and one knonw triterpenoid (16) were isolated from the fruits of S.sphenanthera. The structures of all the isolated compounds were identified by extensive spectroscopic methods including 1D and 2D NMR. All the isolated compounds were tested for their cytotoxicity against Hela, HepG2 and HCT-116 cells. Among the tested compounds, schisanlactone C (16), gomisin D (7) and lancifodilactone L (9) showed significant cytotoxicity.
Keywords: Schisandra sphenanthera Rehd. Et Wils, Schisandraceae , Lignan, Nortriterpenoid, Cytotoxicity
Acknowlegements: This research was supported by a grant(16172MFDS229) from Ministry of Food and Drug Safety in 2018 and by BrainKorea21PLUS program funded by National Research Foundation of Korea.