Artemisia annua L. is the sole natural source of antimalarial drug artemisinin. Endophytic fungi, which spend their life inside the healthy A. annua plants, exhibit intimate impact on the growth and physiology of their hosts and diverse bio-functions: 1) New antimicrobial and antitumor metabolites; 2) The role of plant growth promotion; 3) The regulation on artemisinin biosynthesis; 4) The biodegradation of toxic organic chemicals. The research provided novel references for the rational exploitations on the fungal endophytes in A. annua and for the understanding of mutualism of the plant-endophytes in A. annua.
Acknowledgement: The study is supported by the NNFC (No. 81273487 and 81473183).
Keywords: Artemisia annua ; endophytic fungi; antimicrobe and antitumor; growth promotion; artemisinin; biodegradation
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