16:00 - 18:00
Room: Poster Area - Poster Shed
Poster Presentation
Prenylated Polyphenols from Broussonetia kazinoki as Inhibitors of Nitric Oxide Production
Hana Song 1, Ji Hye Jeong 1, Da Yeon Lee 1, Hwa Jin Lee 2, Jae-Ha Ryu 1
1 College of Pharmacy and Research Center for Cell Fate Control, Sookmyung Women’s University, Seoul
2 School of Industrial Bio-Pharmaceutical Science, Semyung University, Chungbuk

Excessive nitric oxide(NO) production by macrophages has been involved in inflammatory diseases. Seven polyphenols (1–7) were isolated from Broussonetia kazinoki (B. kazinoki) and investigated as potential inhibitors of NO overproduction in lipopolysaccharide (LPS)-activated RAW 264.7 cells. Among them, four prenylated polyphenols (2–4 and 6) with a catechol moiety efficiently suppressed the LPS-induced high level of NO with IC50 values of less than 6 µM. The compounds 2–4 and 6 also attenuated protein and mRNA levels of inducible nitric oxide synthase (iNOS). Moreover, they suppressed the nuclear factor κB (NF-κB) activity by inhibiting the degradation of inhibitory-κB-α (I-κB-α) and the translocation of NF-κB into the nucleus in LPS-activated macrophages. Taken together, these findings suggest that polyphenols from B. kazinoki might be beneficial for treatment of inflammatory diseases.


Reference:
Poster Session-PO-74:
Session:
Poster Presentation-1
Presenter/s:
Hana Song
Presentation type:
Poster presentation
Room:
Poster Area - Poster Shed
Date:
Monday, 27th August, 2018
Time:
16:00 - 18:00
Session times:
16:00 - 18:00