We are living in an era of the wonders of analytical instrumentation, advanced computational chemistry tools and biochemical discoveries that facilitates the isolation, identification of structure and biological activities of natural products. In particular, development of the high resolution NMR spectroscopy equipment beyond 800 MHz resolution, sophisticated NMR techniques, rapid X-ray crystallographic analyses, advanced molecular modeling and docking applications performing on high performance data workstations have revolutionized natural products chemistry and drug discovery studies. In contrast to these developments, examination of natural products papers published in respected journals, compound structures published in well known chemical reference sources, books and/or electronic structure databases reveal many mistakes in the published structures. Many of these structural mistakes suggest the lack of proper stereochemistry training of author(s) and referees. Although these mistakes may not cause any serious issues frequently, nevertheless, when a prospective scientist decides to take the published structure and extrapolate its promising biological activity by synthesis and computational chemistry studies where a misrepresented structure could result in the loss of precious resources and time. Several examples of such misrepresented structures and their possible causes will be discussed during the presentation.