16:00 - 18:00
Room: San Francisco
Poster session
The Heat-clearing and Fire-purging Medicinal Composition for Combating Metastatic Cancer
Dai Yun-Hao 1, 2, Yang Juan-Cheng 1, 2, Kuo Hung-Hsin 2, 3, Wu Yang-Chang 4, 5, 6
1 School of Pharmacy, China Medical University, Taichung, Taiwan
2 Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung, Taiwan
3 Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan
4 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan
5 Research Center for Natural Products & Drug Development, Kaohsiung Medical University, Kaohsiung, Taiwan
6 Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

Traditional Chinese Medicine (TCM) is widely used as alternative therapy for patients who suffer from cancer disease. Accumulating evidence support the notion that cancer may hijack systemic effectors to create microenvironment for cancer progression. This phenomenon is consisted with a theoretic hypothesis based on human systemic health/unhealthy homeostasis for altering disease environment. We learn from experience used of herbal medicine classified as heat-clearing and fire-purging medicine, which have the effect of clearing up internal heat due to yin deficiency. However, lack of scientific evidence to answer the question of how TCM affect cancer cells and alter systemic function is a challenge for translating TCM treatment into clinic. In this study, we look for folk medicine using TCM composition that can improve patients’ outcome. A national health insurance (NHI) program was implemented in 1995. Over 22.6 million individuals from a total population of 23.0 million in Taiwan were enrolled in this insurance program. Observation cohort study was conducted to determine the association between used TCM containing Polygonaceae and Ranunculaceae materials and mortality among the bladder cancer patients. Patients treated with TCM over 135.65g per year significantly reduce hazard ratio compared with Non-TCM user. Using scratch wound healing and time lapse imaging, we demonstrate that the combination of Polygonaceae and Ranunculaceae materials were successfully suppressed the migration of metastatic cancer cells. Furthermore, molecular mechanisms revealed that several molecules such as SOX8 and LHX3 may play an important role for treating metastasis by integrating mRNA and microRNA expression. Collectively, we found that heat-clearing and fire-purging medicinal composition containing two herbs may improve the outcome of metastatic cancer treatment.


Reference:
Tu-Poster Session 2-PO-211:
Session:
Poster Session 2
Presenter/s:
Yang-Chang Wu
Presentation type:
Poster presentation
Room:
San Francisco
Date:
Tuesday, 5th September, 2017
Time:
16:00 - 18:00
Session times:
16:00 - 18:00