11:00 - 12:30
Phytopharmacology / Extract Pharmacology II
Room: Montreal
Lecture Session
Chair/s:
Sandy F van Vuuren
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Beneficial effects of black bean (Rhynchosia volubilis) on ocular surface damage induced by benzalkonium chloride in mouse model of dry eye
Kim KyungA 1, 2, Kang Suk Woo 1, 3, Lee Chung Hyun 4, Yang Sung Jae 4, 5, Kang Tae Kyeom 1, 7, Kim Tae-Jin 6, Jung Sang Hoon 1, 2
1 Natural Products Research Center, Korea Institute of Science and Technology (KIST), Gangneung, Korea, Republic of (South)
2 Division of Bio-Medical Science &Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea., Seoul, Korea, Republic of (South)
3 Research School of Chemistry, Australian National University, Canberra, Australia
4 Department of Ophthalmology, University of Ulsan, Gangneung Asan Hospital, Gangneung, Korea, Republic of (South)
5 Department of Ophthalmology, Oregon Health & Science University, Portland, United States
6 Department of Biological Sciences, Pusan National University, Busan, Korea, Republic of (South)
7 Department of Marine bio-technology, Gangnung-Wonju National University, Gangneung, Korea, Republic of (South)

We investigated the beneficial effect of standardized ethanol extracts of Rhynchosia volubilis (EERV) on an animal model of dry eye (DE). Experimental DE was induced by treatment of 0.2% benzalkonium chlroride (BAC) on cornea in mice [1]. Various concentrations of EERV were daily administered, orally, for 14 after BAC treatment. Treatment of EERV significantly reduced fluorescein staining and increased tear break-up time (BUT). Moreover, treatment of EERV improved morphologically corneal surface regularity compared to DE group. Squamous metaplasia and apoptosis in the cornea were inhibited by treatment of EERV. In addition, treatment of EERV down-regulated the expression of Bax and cytochrome c, while that of BCl-2 was up-regulated against DE. These results demonstrate that EERV has protective effects against BAC-induced corneal damage, and could be as a beneficial agent for treatment of dry eye.

[1] Zhang, Z. et al. Invest. Ophthalmol. Vis. Sci. 2014; 5: 2963-2974

Reference:
Tu-Phytopharmacology / Extract Pharmacology II-SL-06:
Session:
Phytopharmacology / Extract Pharmacology II
Presenter/s:
KyungA Kim
Presentation type:
Short lecture (oral presentation)
Room:
Montreal
Chair/s:
Sandy F van Vuuren
Date:
Tuesday, 5th September, 2017
Time:
12:15 - 12:30
Session times:
11:00 - 12:30
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