GA 2017

Neolitsea acuminatisima (Hayata) Kanehira & Sasaki is genus of Neolistea (Lauraceae), an endemic species in Taiwan. In fact, the chemical constituents of the root of this plant have seldom been investigated previously. It is worth to verify the phytochemistry and secondary metabolites of the root of N. acuminatissima. One new carboline alkaloid, demethoxydaibucarboline A (1) and three new eudesmanolide type sesquiterpenes, methylneolitacumone A (2), neolitacumone E (3), and dineolitacumone C (4), along with twelve known compounds neolitacumones A-C (5-7), b-sitosterol (8), quercetin (9), dihydroquercetin (10), epicatechin (11), oplopanone (12), zeorin (13), linderaggrine A (14), clovane-2β,9α-diol (15), and stigmast-5-ene-3b-yl formate (16) were isolated from the dichloromethane and ethyl acetate-soluble layers of the root of N. acuminatissima. All compounds were obtained by column chromatography and their structures were spectroscopically determined by 1D, 2D NMR and MS. In this present study, the bioactivity of the isolates was also reported.