Shiow-Chyn Huang 1, Ping-Chung Kuo 2, Hsin-Yi Hung 2, Tai-Long Pan 3, Tian-Shung Wu 2
1 Department of Pharmacy, Chia-Nan University of Pharmacy and Science, Tainan 717, Taiwan, Tainan, Taiwan
2 School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan, Tainan, Taiwan
3 School of Traditional Chinese Medicine, Chang Gung University; Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology; Liver Research Center, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan, Taoyuan, Taiwan
The ethanol extract of cultured mycelium of
Phellinus linteus exhibited protective effect against hepatic fibrosis in experimental animals. In the present study, ten new ionone derivatives, phellinulins D-M (
4-
13), were characterized from the mycelium of P. linteus and their structures were established on the basis of spectroscopic and spectrometric analysis. Part of the purified compounds were subjected to the examination of their effects on activated rat hepatic stellate cells and several isolates exhibited significant inhibition of hepatic fibrosis. The results indicated that the mycelium of P. linteus had potential to be developed as hepatoprotective drugs or healthy food in the future.
