16:00 - 18:00
Poster Session 1
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Benzoyltyramine Alkaloids Atalantums A-G with Their Cytotoxicity against Cholangiocarcinoma Cell Line from the Peels of Atalantia monophylla
Sribuhom Thurdpong 1, Boueroy Parichart 2, Hahnvajanawong Chariya 2, Phatchana Ratchanee 3, Yenjai Chavi 1
1 Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand, Khon Kaen, Thailand
2 Department of Microbiology, Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand, Khon Kaen, Thailand
3 Department of Chemistry, Faculty of Engineering, Rajamangala University of Technology Isan, Khon Kaen Campus, Khon Kaen 40000, Thailand, Khon Kaen, Thailand

Abstract

The extraction and isolation of the peels of Atalantia monophylla using chromatographic methods afforded seven new benzoyltyramines, atalantums A–G (1-7), along with five known compounds [1]. The structures of these compounds were elucidated based on the analysis of spectroscopic data. Compound 5 displayed the strongest cytotoxicity against KKU-M156 cells, with an IC50 value of 1.97 ± 0.73 μM, an approximately 4.7-fold higher activity than that of the ellipticine standard [2]. Compound 1 was active against KKU-M214 cells, with an IC50 value of 3.06 ± 0.51 µM. For KKU-M213 cell line, compounds 2, 4, and 11 displayed stronger cytotoxicity than the ellipticine standard, with IC50 values of 2.36 ± 0.20, 5.63 ± 0.22, and 2.71 ± 0.23 μM, respectively. Compounds 1, 5, and 7 displayed cytotoxicity against KKU-M214 cells, with IC50 values of 3.06 ± 0.51, 8.44 ± 0.47, and 7.37 ± 1.29 μM, respectively [3].

Reference

[1] Panda H. Handbook on Medicinal Herbs with Uses: Asia Pacific Business Press Inc; 2004: 166 − 167.

[2] Loilome W, Yongvanit P, Wongkham C, Tepsiri N, Sripa B, Sithithaworn P, Hanai S, Miwa M. Mol. Carcinog 2006; 45 (5): 279-287.

[3] Sribuhom T, Boueroy P, Hahnvajanawong C, Phatchana R, Yenjai C. J. Nat. Prod 2017; 80: 403-408.

Reference:
Mo-Poster Session 1-PO-93:
Session:
Poster Session 1
Presenter/s:
Thurdpong Sribuhom
Presentation type:
Poster presentation
Room:
San Francisco
Date:
Monday, 4th September, 2017
Time:
16:00 - 18:00
Session times:
16:00 - 18:00
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