Ping-Chung Kuo, Hsin-Yi Hung, Tian-Shung Wu
1. School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan, Tainan, Taiwan
Fifty compounds were isolated from the fruits of
Forsythia suspensa, including 13 new compounds characterized as eight new diterpenoids (
1-
8), three new lignans (
9-
11), a new iridoid (
12), and a new triterpenoid (
13). Their structures were established on the basis of spectroscopic and spectrometric analysis. Most of the isolated compounds were examined for their anti-inflammatory activity in vitro. The results showed that several compounds displayed significant inhibition of fMLP/CB-induced superoxide anion generation and elastase release, with IC
50 values ranging from 0.6 ± 0.1 to 8.6 ± 0.8 μg/mL and from 0.8 ± 0.3 to 7.3 ± 1.1 μg/mL, respectively.
